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Supplement Moderate

Magnesium: What It Does, Which Form to Take, and How Much

Close to half of Americans eat less magnesium than recommended, and the benefits concentrate in people who were short to begin with. Beyond that, magnesium is a dependable laxative and a modest help for migraine and blood pressure. It does little for sleep, and the best trials find nothing for the night leg cramps it is most often sold for.

Magnesium is a mineral used throughout the body's cells, most of it stored inside cells and bone, with very little in the blood. You get it from leafy greens, nuts, seeds, legumes, and whole grains, and a diet light on those runs low. A few common medicines, including proton pump inhibitors and diuretics, lower it further. Because so little magnesium circulates in blood, a standard blood test can read normal even when whole-body stores are low.

The evidence sorts cleanly by how strong it is. As an osmotic laxative, magnesium works well and fast: in trials of magnesium oxide for constipation, about 70% improved against 25% on placebo. Daily high-dose magnesium is rated possibly effective for migraine prevention. Across 34 randomized trials it lowered systolic blood pressure by about 2 mmHg, more in people who started low. People who eat more magnesium also have less heart failure and diabetes over the years. That comes from cohort data, which shows a pattern but cannot prove the mineral alone drives it.

For sleep, the pooled evidence is three small trials in older adults, where magnesium shaved about 17 minutes off the time it took to fall asleep, on evidence the reviewers rated low to very low quality. For anxiety, roughly half of trials in anxiety-prone people showed a benefit and half showed nothing, and most of those trials paired magnesium with vitamin B6, so magnesium alone cannot take the credit. For the night leg cramps it is marketed for hardest, a Cochrane review found no meaningful benefit over placebo in older adults.

Food comes first: a magnesium-rich diet brings fiber, potassium, and plant compounds along with the mineral. If you supplement, match the form to the goal: magnesium glycinate or citrate for raising body magnesium, magnesium oxide only if you specifically want the laxative effect, since it is poorly absorbed. A typical dose is 200 to 400 mg of elemental magnesium a day with food; loose stools mean you have gone past what you need. Anyone with reduced kidney function should check with a clinician first, since the kidney is what clears the excess.

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272 Topics

Every topic, grouped by area. Practices, conditions, supplements, the science underneath, and the tools.

Metabolic & Nutrition38 Topics
Diet & nutrition
The Mediterranean Diet: What It Does, Why It Works, and How to StartIntake Sodium Reduction & DASH Diet: What Lowers Blood Pressure, and How to Do ItIntake Is Buying Organic Worth It?Intake Green Tea and Matcha: What It Does, and the One CatchIntake Protein and Muscle: the dose, the sources, and building itIntake Seed Oils: What the Evidence ShowsIntake The Post-Meal Walk: How Soon, How Long, and What It Actually LowersTraining Alcohol and Your Health: What the Evidence Shows NowIntake Whole Foods and Ultra-Processed Foods: What the Evidence Shows and How to Eat WellIntake Hydration and Electrolytes: How Much Water You Need, and When Salt Actually MattersIntake Dietary Fiber: What Each Type Does and How Much to EatIntake The Carnivore Diet: What It Is, What People Report, and What Is Actually KnownIntake
Supplements47 Topics
Longevity & cellular
Cocoa Flavanols: What They Do for Blood Pressure, Arteries and MemorySupplement NAC and Glycine: A Proven Antidote, a Steady Mucolytic, and the GlyNAC Longevity StorySupplement Alpha-Lipoic Acid: Strongest for Diabetic Nerve PainSupplement Taurine: The Aging Headline, and What the Evidence ShowsSupplement Urolithin A: What It Does for Mitochondria and MuscleSupplement Fisetin and Quercetin: The Senolytic Supplements, and What Humans Actually HaveSupplement Sulforaphane and Broccoli Sprouts: Strong Mechanism, Early Human EvidenceSupplement Resveratrol: The Red-Wine Longevity Story, and What the Trials ShowSupplement Spermidine: A Strong Lab Case and a Thin Human RecordSupplement Coenzyme Q10: What the Trials Show for Heart Failure, Migraine, and Statin Muscle PainSupplement Ergothioneine: The Mushroom Antioxidant and the Longevity-Vitamin QuestionSupplement
Frontier25 Topics
Clinical & testing
Metformin: A Proven Diabetes Drug and the Open Longevity QuestionDrug SGLT2 Inhibitors: Kidney Glucose Drugs at the Edge of the Longevity QuestionDrug Rapamycin: The Strongest Animal Longevity Drug, and Where the Human Evidence StandsDrug Senolytics: Clearing Worn-Out Cells, the Mouse Data, and Where the Human Trials AreDrug Ivermectin: A Nobel-Winning Antiparasitic, and the COVID Story in FullDrug Low-Dose Naltrexone (LDN): What the Evidence Shows, and Where It StopsDrug Stem Cells and Exosomes: The Proven Uses, the Clinic Market, and Where the Harm IsServices Acarbose: The Old Diabetes Drug That Extends Life in MiceDrug Therapeutic Plasma Exchange and the Young-Plasma Trend: Established Medicine and the Longevity FrontierServices Growth Hormone Secretagogues: What Ibutamoren and the GH Peptides DoDrug Peptides: The Few Approved Drugs and the Many Unregulated OnesDrug Hyperbaric Oxygen Therapy: What It Treats, and Where the Wellness Claims Exceed the EvidenceServices Prolotherapy and Regenerative InjectionsServices Whole-Body CryotherapyExposure IV Vitamin Drips and NAD+ Therapy: What the Evidence ShowsServices Ozone Therapy: What the Evidence ShowsServices