Sacred Lotus Chinese & Integrative Medicine

Relationship Graph

Sacred Lotus connections

Chinese Herb Safety

This is a reference, not medical advice. Before combining any herb with another herb, a supplement, or a medication, consult a qualified practitioner and your pharmacist or physician.

The five safety/warning tags on 129 Chinese herbs.

  • Drug interactions — documented interactions with medications, with a derived risk level and interaction type (blood thinners, blood sugar, liver metabolism, and more).
  • Incompatible · 十八反 — the classical "Eighteen Incompatibilities": herb pairs that must not be combined.
  • Antagonizes · 十九畏 — the "Nineteen Antagonisms": herb pairs that mutually blunt or counteract each other.
  • Toxic / restricted — herbs that are toxic, or restricted/illegal in the United States, with a toxicity note.
  • Endangered / illegal — substances from CITES-protected species (e.g. tiger, rhinoceros, pangolin, saiga antelope, seahorse) that are illegal and must be replaced with humane, legal substitutes.

These flags describe what we document; the interaction risk level is not a clinical severity score. Always read a herb's full page and confirm with a qualified practitioner and pharmacist.


Risk
Interacts With

Showing 129 of 129 herbs with a safety flag.

  • Ba Dou十九畏 AntagonizesToxic / restricted
    Croton Seed (Crotonis Fructus)

    Antagonizes / antagonized by 十九畏: Qian Niu Zi

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Bai Fu ZiToxic / restricted
    Typhonium Rhizome (Rhizoma Typhonii Gigantei)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Bai GuoToxic / restricted
    Ginkgo Nut (Semen Ginkgonis Bilobae)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Bai Hua SheHigher interactionToxic / restricted
    Agkistrodon, Bungarus (Agkistrodon Seu Bungarus)
    Bleeding / Blood ThinnersToxic / Restricted Herb

    As Bai Hua She has an anticoagulant effect, it should be used with extreme caution when taking anti-platelet or anti-coagulant drugs.

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Bai Ji十八反 Incompatible
    Bletilla Rhizome (Rhizoma Bletillae)

    Incompatible with 十八反: Fu Zi, Cao Wu, Chuan Wu

  • Bai Lian十八反 Incompatible
    Ampelopsis, Japanese Ampelopsis Root (Radix Ampelopsis)

    Incompatible with 十八反: Fu Zi, Cao Wu, Chuan Wu

  • Bai Shao十八反 Incompatible
    White Peony Root (Radix Albus Paeoniae Lactiflorae)

    Incompatible with 十八反: Li Lu

  • Ban Bian LianModerate interaction
    Chinese Lobelia, Lobelia (Herba Lobeliae Chinensis Gum Radice)
    Blood Pressure

    Ban Bian Lian has a diuretic effect and should be taken with care with other diuretic drugs including Lasix, Bumex, and Demadex.

  • Ban MaoToxic / restricted
    Cantharides (Mylabris)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Ban Xia十八反 IncompatibleToxic / restricted
    Pinellia Rhizome (Rhizoma Pinelliae Tematae)

    Incompatible with 十八反: Fu Zi, Cao Wu, Chuan Wu

    Toxicity: Fresh Ban Xia is toxic and should only be used topically, and even this may cause redness or itching throughout the body.

  • Bei Sha Shen十八反 Incompatible
    Glehnia Root (Radix Glehniae Littoralis)

    Incompatible with 十八反: Li Lu

  • Bei XieGeneral interaction
    Fish Poison Yam Rhizome, Tokoro (Rhizoma Dioscoreae Hypoglaucae)
  • Cang Er ZiToxic / restricted
    Cocklebur Fruit (Fructus Xanthii Siberici)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Cang ZhuGeneral interaction
    Black Atractylodes Rhizone (Rhizoma Atractylodis)

    May interfere with Anti-Diabetic drugs.

  • Cao Wu十八反 Incompatible十九畏 AntagonizesToxic / restricted
    Prepared Wild Aconite (Radix Aconiti Kusnezoffii Preparata)

    Incompatible with 十八反: Bai Ji, Ban Xia, Chuan Bei Mu, Gua Lou, Gua Lou Pi, Gua Lou Ren, Tian Hua Fen, Zhe Bei Mu, Bai Lian

    Antagonizes / antagonized by 十九畏: Xi Jiao

    Toxicity: Extremely toxic — use only the properly prepared form, and only under qualified supervision.

  • Chan SuToxic / restricted
    Toad Venom, Dried Toad Skin Secretions (Secretio Bufonis)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Chang ShanToxic / restricted
    Dichroa Root (Radix Dichroae Febrifugae)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Che Qian ZiModerate interaction
    Plantago Seed, Plantain Seed (Semen Plantaginis)
    Blood Pressure

    Che Qian Zi promotes urination and may interfere with Diuretic drugs.

  • Chi Shao十八反 Incompatible
    Red Peony Root (Radix Rubrus Paeoniae Lactiflorae)

    Incompatible with 十八反: Li Lu

  • Chi Shi ZhiGeneral interaction十九畏 Antagonizes
    Halloysite, Kaolin (Hallyositum Rubrum)

    Chi Shi Zhi has the ability to bind to other substances in the gastrointestinal tract forming a solid mass that has limited absorption in the intestines. For this reason, drugs should be taken a few hours before or after the ingestion…

    Antagonizes / antagonized by 十九畏: Rou Gui

  • Chuan Bei Mu十八反 Incompatible
    Tendrilled Fritillaria Bulb (Bulbus Fritillariae Cirrhosae)

    Incompatible with 十八反: Fu Zi, Cao Wu, Chuan Wu

  • Chuan JiaoToxic / restricted
    Fruit of Szechuan Pepper (Pericarpium Zanthoxyli Bungeani)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Chuan Lian ZiToxic / restricted
    Sichuan Pagoda Tree Fruit (Fructus Meliae Toosendan)

    Toxicity: Unprocessed Chuan Lian Zi is Slightly Toxic.

  • Chuan Mu TongModerate interaction
    Clematis (Caulis Clematidis Armandii)
    Blood Pressure

    Chuan Mu Tong promotes urination and may interfere with Diuretic drugs.

  • Chuan Shan JiaEndangered
    Anteater Scales, Pangolin Scales (Squama Manitis Pentadactylis)
  • Chuan Wu十八反 Incompatible十九畏 AntagonizesToxic / restricted
    Prepared Sichuan Aconite (Radix Aconiti Preparata)

    Incompatible with 十八反: Bai Ji, Ban Xia, Chuan Bei Mu, Gua Lou, Gua Lou Pi, Gua Lou Ren, Tian Hua Fen, Zhe Bei Mu, Bai Lian

    Antagonizes / antagonized by 十九畏: Xi Jiao

    Toxicity: Extremely toxic — use only the properly prepared form, and only under qualified supervision.

  • Chuan XiongGeneral interaction
    Szechuan Lovage Root (Rhizoma Ligustici Chuanxiong)

    Chuan Xiong may interfere with Anti-Coagulating drugs.

  • Da Feng ZiToxic / restricted
    Chaulmoogra Seeds (Semen Hydnocarpi Anthelminticae)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Da JiHigher interaction十八反 Incompatible
    Japanese Thistle, Cirsium (Herba Cirsii Japonici)
    Bleeding / Blood Thinners

    Use with caution in patients taking warfarin or other blood thinners to avoid blood clots, but no adverse effect has been documented.

    Incompatible with 十八反: Gan Cao

  • Dan ShenHigher interaction十八反 Incompatible
    Salvia Root (Radix Salviae Miltiorrhizae)
    Bleeding / Blood Thinners

    Dan Shen may interfere with Anti-Coagulating drugs. Decreases warfarin clearance and increases its bioavailability.

    Incompatible with 十八反: Li Lu

  • Dang GuiGeneral interaction
    Chinese Angelica Root (Radix Angelicae Sinensis)

    Dang Gui may interfere with Anti-Coagulating drugs.

  • Dang Shen十八反 Incompatible
    Codonopsis Root (Radix Codonopsitis Pilosulae)

    Incompatible with 十八反: Li Lu

  • Deng Xin CaoGeneral interaction
    Rush Pith, Juncus (Medulla Junci Effusi)
  • Ding Xiang十九畏 Antagonizes
    Clove Flower Bud (Flos Caryophylli)

    Antagonizes / antagonized by 十九畏: Yu Jin

  • Dong Gua PiGeneral interaction
    Winter Melon Peel, Wax Gourd Peel (Exocarpium Benincasae)
  • Dong Gua ZiGeneral interaction
    Winter Melon, Wax Gourd Seed, Benincasa (Semen Benincasae Hispidae)
  • Dong Kui ZiGeneral interaction
    Musk Mallow Seeds, Abutilon Seeds (Semen Malvae)

    Care should be used in patients taking diuretics like Lasix.

  • Feng FangToxic / restricted
    Hornet's Nest (Nidus Vespae)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Fu Ling PiModerate interaction
    Poria Skin (Sclerotii Poriae Cocos)
    Blood Pressure

    None noted but this herb has a diuretic effect and care should be used when taken with other diuretics

  • Fu ShenModerate interaction
    Poria Spirit (Scierotium Pararadicis Poriae Cocos)
    Blood Pressure

    None noted, but this herb has a mild diuretic effect and care should be used in patients taking diuretics.

  • Fu Zi十八反 IncompatibleToxic / restricted
    Processed Aconite (Radix Lateralis Praeparatus Aconiti Carmichaeli)

    Incompatible with 十八反: Bai Ji, Ban Xia, Chuan Bei Mu, Gua Lou, Gua Lou Pi, Gua Lou Ren, Tian Hua Fen, Zhe Bei Mu, Bai Lian

    Toxicity: This herb is Toxic.

  • Gan CaoGeneral interaction十八反 Incompatible
    Licorice Root (Radix Glycyrrhizae)

    Corticosteroids: Glycyrrhizin, a compount in Gan Cao may prolong the biological half-life of the sytemic corticosteroids. 12, 25 Digioxin: Potassium loss associated with Gan Cao may increase toxicity of cardiac glycosides such as…

    Incompatible with 十八反: Da Ji, Jing Da Ji, Gan Sui, Hai Zao, Yuan Hua

  • Gan QiToxic / restricted
    Sap Prepared as Lacquer (Lacca Sinica Exsiccata)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Gan Sui十八反 IncompatibleToxic / restricted
    Kansui Root (Radix Euphorbiae Kansui)

    Incompatible with 十八反: Gan Cao

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Gua DiToxic / restricted
    Melon Pedicle (Pedicellus Cucumeris)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Gua Lou十八反 Incompatible
    Trichosanthes Fruit (Fructus Trichosanthis Kirlowii)

    Incompatible with 十八反: Fu Zi, Cao Wu, Chuan Wu

  • Gua Lou Pi十八反 Incompatible
    Trichosanthes Peel, Snake Gourd Peel (Pericarpium Trichosanthis Kirlowii)

    Incompatible with 十八反: Fu Zi, Cao Wu, Chuan Wu

  • Gua Lou Ren十八反 Incompatible
    Trichosanthes Seeds (Semen Trichosanthis Kirlowii)

    Incompatible with 十八反: Fu Zi, Cao Wu, Chuan Wu

  • Guang Fang JiHigher interactionToxic / restricted
    Aristolochia Root, Stephania (Radix Aristolochiae Fangchi)
    Toxic / Restricted Herb

    This herb should not be used with other nephrotoxic or hepatotoxic compounds.

    Toxicity: This herb is banned due to its toxicity This herb contains aristolochic acid, a compound that can cause permanent kidney damage, including kidney failure. It has also been shown to cause cancer,…

  • Hai Zao十八反 Incompatible
    Seaweed, Sargassum (Herba Sargassii)

    Incompatible with 十八反: Gan Cao

  • Han Fang JiGeneral interaction
    Stephania Root (Radix Stephaniae Tetrandrae)

    None noted, but use cautiously with diuretics including chlorothoiazide, hydrochlorothiazide, Lasix, Bumex, and Demadex.

  • Han Lian CaoGeneral interaction
    Eclipta (Herba Ecliptae Prostratae)
  • He ShiToxic / restricted
    Carpesium Fruit (Fructus Carpesii Seu Dauci)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Hei Zhi MaGeneral interaction
    Black Sesame Seeds (black Semen Sesame Indici)
  • Hong Da JiToxic / restricted
    Knoxia Root (Radix Knoxiae)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Hong HuaGeneral interaction
    Safflower Flower (Flos Carthami Tinctorii)

    Hong Hua may interfere with Anti-Coagulating drugs.

  • Hou PoHigher interaction
    Magnolia Bark (Cortex Magnoliae Officinalis)
    Bleeding / Blood Thinners

    Hou Po contains magnolol, a mild anticoagulant. Caution should be used in patients taking antiplatelets or anticoagulants including; aspirin, dipyridamole, clopidogrel(plavix), heparin, warfarin, and enoxaparin(Lovenox).

  • Hu GuEndangered
    Tiger Bone (Os Tigris)

    Toxicity: None Noted

  • Hua ShiGeneral interaction
    Talcum (Talcum)
  • Huang QiGeneral interaction
    Astragalus (Radix Astragali Membranacei)

    May interfere with Anti-Diabetic drugs.

  • Huo XiangGeneral interaction
    Patchouli, Agastache (Herba Agastaches Rugosus, Herba Pogostemonis)
  • Jin Qian CaoModerate interaction
    Lysimachia (Herba Desmodii Styrachifolii)
    Blood Pressure

    Due to Jin Qian Cao’s diuretic affect, use caution in patients taking diuretics.

  • Jing Da Ji十八反 IncompatibleToxic / restricted
    Peking Spurge Root (Radix Euphorbiae Pekinensis)

    Incompatible with 十八反: Gan Cao

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Ku Lian Gen PiToxic / restricted
    China Tree Root Bark (Cortex Meliae Radicis)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Ku Shen十八反 Incompatible
    Sophora Root (Radix Sophorae Flavescentis)

    Incompatible with 十八反: Li Lu

  • Lei WanToxic / restricted
    Fruiting Body of Omphalia (Scierotium Omphaliae Lapidescentis)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Li Lu十八反 IncompatibleToxic / restricted
    Veratrum Root and Rhizome (Radix Et Rhizoma Veratri)

    Incompatible with 十八反: Bai Shao, Bei Sha Shen, Chi Shao, Dan Shen, Dang Shen, Ku Shen, Ren Shen, Xi Xin, Xuan Shen, Sha Shen

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Liu Huang十九畏 AntagonizesToxic / restricted
    Sulpher (Sulphur)

    Antagonizes / antagonized by 十九畏: Po Xiao

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Luo Han GuoGeneral interaction
    Momordica Fruit (Fructus Momordicae Grosvenori)
  • Ma Dou LingToxic / restricted
    Birthwort Fruit (Aristolochiae Fructus)

    Toxicity: This herb contains aristolochic acid, a compound that can cause permanent kidney damage, including kidney failure. It has also been shown to cause cancer, specifically urothelial carcinoma. Position paper…

  • Ma HuangModerate interaction
    Ephedra Stem (Herba Ephedrae)
    Blood Pressure

    Ma Huang contains ephedrine and pseudoephedrine which interferes with Sympathomimic (anti-seizure) and Cariovascular drugs. Ma Huang (Ephedra) and MAOI can cause dangerously high blood pressure. FDA proposed a dosage limit of 8 mg every…

  • Ma Qian ZiToxic / restricted
    Nux Vomica Seeds (Semen Strychnotis)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Mai Men DongGeneral interaction
    Ophiopogon Tuber (Tuber Ophiopogonis Japonici)
  • Meng ChongToxic / restricted
    tabanus, gadfly (Tabanus)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Mi Tuo SengToxic / restricted
    Litharge (Lithargyrum)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Mu Bie ZiToxic / restricted
    Momordica Seeds (Semen Momordicae Cochinchinensis)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Nu Zhen ZiModerate interaction
    Privet Fruit, Ligustrum (Fructus Ligustri Lucidi)
    Blood Sugar

    Nu Zhen Zi lowers plasma glucose levels. Combining this herb with anti-diabetic medication such as insulin or sulfonylureas may result in hypoglycemia. 12

  • Pei LanGeneral interaction
    Eupatorium (Herba Eupatorii Fortunei)
  • Po XiaoGeneral interaction十九畏 Antagonizes
    (Sal Glauberis)

    Please see Mang Xiao

    Antagonizes / antagonized by 十九畏: Liu Huang

  • Qian DanToxic / restricted
    Lead Oxide (Minium)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Qian Niu Zi十九畏 AntagonizesToxic / restricted
    Morning Glory Seeds or Pharbitis (Semen Pharbiditis)

    Antagonizes / antagonized by 十九畏: Ba Dou

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Qing FenToxic / restricted
    Calomel (Calomelas)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Qu MaiGeneral interaction
    Aerial Parts of Fringed Pink or Chinese Pink Dianthus (Herba Dianthi)

    Use with caution in patients taking diuretics since this herb promotes urination.

  • Quan XieToxic / restricted
    Scorpion, Buthus (Buthus Martensis)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Ren ShenGeneral interaction十八反 Incompatible十九畏 Antagonizes
    Ginseng Root (Radix Ginseng)

    It is suggested, but not documented that Ren Shen (Radix Ginseng) may induce mania in depressed patients that mix this herb with phenelzine antidepressants. 12 An in vitro study suggests that an herbal preparation of Ren Shen (Radix…

    Incompatible with 十八反: Li Lu

    Antagonizes / antagonized by 十九畏: Wu Ling Zhi

  • Rou Gui十九畏 Antagonizes
    Inner Bark of Saigon Cinnamon (Cortex Cinnamomi Cassiae)

    Antagonizes / antagonized by 十九畏: Chi Shi Zhi

  • San Leng十九畏 Antagonizes
    Bur Reed Rhizome (Rhizoma Sparganii)

    Antagonizes / antagonized by 十九畏: Ya Xiao

  • Sha RenModerate interaction
    Cardamom (Grains of Paradise Fruit) (Fructus Amomi)
    Bleeding / Blood Thinners

    Sha Ren has anti-platelet action and caution should be used with patients taking antiplatelet or anticoagulant meds. This possible interaction is undocumented.

  • Sha ShenGeneral interaction十八反 Incompatible
    Adenophora Root, Four Leaf Lady Bell Root (Glehniae/Adenophorae Radix)

    None Noted.

    Incompatible with 十八反: Li Lu

  • Shan Ci GuToxic / restricted
    Bulb of Chinese Tulip (Pseudobulbus Shancigu)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Shan YaoGeneral interaction
    Chinese Yam Rhizome, Dioscorea (Radix Dioscoreae Oppositae)

    May interfere with Anti-Diabetic drugs.

  • Shang LuToxic / restricted
    Poke Root or Phytolacca (Radix Phytolaccae)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • She XiangEndangered
    Deer Musk (Secretio Moschi Moschifeni)
  • Shi GaoGeneral interaction
    Gypsum (Gypsum Fibrosum)

    May interfere with Anti-Diabetic drugs.

  • Shi Liu PiToxic / restricted
    Pomegranate Husk (Penicarpium Punicae Granati)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Shi WeiGeneral interaction
    Pyrrosia Leaves (Herba Pyrrosiae)
  • Shu Di HuangGeneral interaction
    Chinese Foxglove Root, Steamed with Water or Alcohol, Rehmannia (Processed Radix Rehmanniae)
  • Shui ZhiGeneral interactionToxic / restricted
    Leech (Hirudo seu Whitmania)
    Toxic / Restricted Herb

    Shui Zhi may interfere with Anti-Coagulating drugs.

    Toxicity: Overdose symptoms occur 1-4 hours after ingestion. Symptoms include nausea, vomiting, metrorrhagia, gastrointestinal hemorrhage, severe abdominal pain, hematuria, and coma.

  • Tao RenGeneral interaction
    Peach Kernel (Semen Pruni Persicae)

    Tao Ren may interfere with Anti-Coagulating drugs.

  • Tian Hua Fen十八反 Incompatible
    Trichosanthes Root (Trichosanthis Kirlowii Radix)

    Incompatible with 十八反: Fu Zi, Cao Wu, Chuan Wu

  • Tong CaoModerate interaction
    Rice Paper Pith, Tetrapanax (Medulla Tetrapanacis Papyriferi)
    Blood Pressure

    Due to the diuretic effect of this herb, care should be used when taking prescription diuretics.

  • Tu Bie ChongToxic / restricted
    Wingless Cockroach (Eupolyphaga Seu Opistholpatia)

    Toxicity: Slightly Toxic with symptoms like sinus bradycardia, general weakness, nausea, vertigo, irritation of the GI tract. Contact dermatitis is possible with topical application.

  • Wu GongToxic / restricted
    Centipede (Scolopendra Subspinipes)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Wu Ling Zhi十九畏 Antagonizes
    Flying Squirrel Feces (Feces Trogopterori Seu Pteromi)

    Antagonizes / antagonized by 十九畏: Ren Shen

  • Wu Zhu YuToxic / restricted
    Evodia Fruit (Fructus Evodiae Rutaecarpae)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Xi Jiao十九畏 AntagonizesEndangered
    Rhinoceros Horn (Cornu Rhinoceri)

    Antagonizes / antagonized by 十九畏: Cao Wu, Chuan Wu

  • Xi Xin十八反 Incompatible
    Chinese Wild Ginger, Asarum (Herba Asari Cum Radice)

    Incompatible with 十八反: Li Lu

  • Xian MaoToxic / restricted
    Golden Eye Grass Rhizome (Rhizoma Curculiginis Orchioidis)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Xing RenToxic / restricted
    Apricot Seed or Kernel (Semen Pruni Armeniacae)

    Toxicity: Slightly toxic — use only the properly prepared form, and only under qualified supervision.

  • Xiong HuangToxic / restricted
    Realgar (Realgar)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Xuan ShenGeneral interaction十八反 Incompatible
    Ningpo Figwort Root (Radix Scrophulariae Ningpoensis)

    May interfere with Anti-Diabetic drugs.

    Incompatible with 十八反: Li Lu

  • Ya Dan ZiToxic / restricted
    Java Brucea Fruit (Fructus Bruceae Javanicae)

    Toxicity: Large doses can cause vasodilation of the internal organs and may lead to hemorrhage.

  • Ya Xiao十九畏 Antagonizes
    (Nitrum)

    Antagonizes / antagonized by 十九畏: San Leng

  • Yi Yi RenGeneral interaction
    Seeds of Job's Tears (Semen Coicis Lachyrma-jobi)
  • Yin ChenModerate interaction
    Yinchenhao Shoots and Leaves, Capillaris (Herba Artemisiae Yinchenhao)
    Blood Pressure

    None noted, but caution should be used when combining with diuretic drugs.

  • Ying Su KeToxic / restricted
    Opium Poppy Husk (Pericarpium Papaveris Somniferi)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Yu Jin十九畏 Antagonizes
    Turmeric Tuber (Tuber Curcumae)

    Antagonizes / antagonized by 十九畏: Ding Xiang

  • Yu Mi XuHigher interaction
    Cornsilk (Stylus Zeae Mays)

    Caution should be used when using prescription diuretics though adverse interactions are undocumented. Caution should be used when taking coumadin since this herb contains vitamin K, which affects clotting time.

  • Yuan Hua十八反 IncompatibleToxic / restricted
    Genkwa Flower (Flos Daphnis Genkwae)

    Incompatible with 十八反: Gan Cao

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Yuan Ming FenGeneral interaction
    (Matrii Sulfas Exsiccatus)

    Please See Mang Xiao

  • Zao JiaoToxic / restricted
    Chinese Honeylocust Fruit (Gleditsiae Sinensis Fructus)

    Toxicity: Doses in excess of 30 grams can lead to hemolytic anemia. This herb is toxic, overdose can lead to dry mouth, nausea, vomiting, restlessness, diarrhea, burning sensation of the epigastrum, irritability and…

  • Ze QiToxic / restricted
    Euphorbia (Euphorbiae Helioscopiae)

    Toxicity: Initial symptoms of toxic overdose or long term use are epigastric discomfort and pain. Severe cases include severe abdominal pain, diarrhea, nausea, vomiting, dizziness, headache, restlessness,…

  • Ze XieModerate interaction
    Water Plantain Rhizome, Alisma (Rhizoma Alismatis)
    Blood Pressure

    Ze Xie promotes urination and may interfere with Diuretic drugs (ie - Lasix).

  • Zhang NaoToxic / restricted
    Camphor (Camphora)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

  • Zhe Bei Mu十八反 Incompatible
    Thunberg Fritillaria Bulb (Fritillariae Thunbergii Bulbus)

    Incompatible with 十八反: Fu Zi, Cao Wu, Chuan Wu

  • Zhi MuGeneral interaction
    Anemarrhena Rhizome (Rhizoma Anemarrhenae Aspheloidis)

    May interfere with Anti-Diabetic drugs.

  • Zhi Tian Nan XingToxic / restricted
    Prepared Jack in the Pulpit Rhizome (Arisaematis Rhizoma preparatum)

    Toxicity: The entire plant is toxic and unsuitable for ingestion unless pre-processed, usually with ginger. Overdose of processed herb leads to numbness of the extremities, paralysis and numbness of the mouth and…

  • Zhu LingGeneral interaction
    Polyporus Sclerotium (Sclerotium Polypori Umbellati)

    Caution should be used in patients taking prescribed diuretics though no adverse events are documented.

  • Zhu ShaToxic / restricted
    Cinnabar (Cinnabar)

    Toxicity: Toxic — use only the properly prepared form, and only under qualified supervision.

Please read — this list is not complete

While we have made every effort to catalog herb interactions, incompatibilities, and toxicities, these are deep, complex, and still-developing fields. These lists cannot be exhaustive. Cautions beyond those documented here undoubtedly exist, new ones are reported as research advances, and a herb's absence from a list is not evidence that it is safe. Treat this as a starting point for a conversation with a qualified practitioner, pharmacist, or physician — never as a final clearance.

For how we research, cross-reference, and grade the evidence behind these entries, see How we source our content .